Treating the Impact of Seizures on Cardiac Function to Reduce Death

The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy

HM Lee, XN Gan, KP Aung, IC Forster, CA Reid, MS Soh

2026-04-01

Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of mortality in patients in epilepsy, yet its underlying mechanis..

Atenolol rescues premature mortality in genetic mouse models of sudden unexpected death in epilepsy

MS Soh, A Hu, A Kuanyshbek, ES Mohamed Syazwan, HM Lee, CE McKenzie, AM Phillips, LE Bleakley, C Semsarian, IE Scheffer, SF Berkovic, CA Reid

2026-01-01

Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of premature mortality in epilepsy. Genetic studies ha..

Kv1.1 channels in cardiorespiratory regulation and sudden unexpected death in epilepsy: insights from mouse models

A Hu, KP Aung, CA Reid, MS Soh

2025-01-01

This scientific commentary refers to 'Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuit..

WONOEP appraisal: Modeling early onset epilepsies

AS De Meulemeester, C Reid, S Auvin, PL Carlen, AJ Cole, R Szlendak, R Di Sapia, SL Moshé, R Sankar, TJ O'Brien, S Baulac, DC Henshall, Ö Akman, AS Galanopoulou

2024-09-01

Epilepsy has a peak incidence during the neonatal to early childhood period. These early onset epilepsies may be severe conditions..